First Food-Matrix / Oleoresin-Based Curcumin
Bioavailable . Dispersible . Palatable
First Food-Matrix / Oleoresin-Based Curcumin
Bioavailable . Dispersible . Palatable
Curcuminoids, turmeric essential oils and resins are naturally housed within the turmeric oleoresin. They are exclusively represented in Curcugen® and complemented by a diverse spectrum of other turmeric native compounds. Curcugen’s full-spectrum profile benefits from the strategic and patent-protected application of safe, food-grade solvents and precipitants.
Curcugen® is the only oleoresin-sourced turmeric active on the market to generate its absorption benefit from the dispersion power found in a previously ignored turmeric native – ‘polar’ resins.
Curcugen® uniquely delivers the same ratio of curcuminoid analogues – curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) – as found in the turmeric rhizome in its food state, or as its primary derivative, the oleoresin. While Curcugen® is concentrated to a 50% standard of curcuminoids, it is not hyper-purified, as is common with other curcuminoid formulations. Therein, Curcugen® retains a closely matched ratio of these cousin-molecules to what is natural, and found most familiarly in food.
In an 18-subject, cross-over pharmacokinetics study over 24-hours, Curcugen®, at 2000 mg of curcuminoids equivalents enhanced FREE-curcumin bioavailability by 39X that of placebo, and proved 52.5-times more bioavailable for Total Curcuminoids than standardized curcumin 95% (C-95).
Curcugen® is one of the first curcuminoids formulas to prove an increase in the bioavailability of endogenously-produced tetrahydrocurcumin (THC). THC is thought to be a more potent antioxidant than curcumin, although curcuminoid analogues appear to still offer more potent inflammatory signal modulation than THC. Curcugen® enhanced total THC bioavailability by 31X over C-95.
Curcugen’s efficacy is backed by several, published clinical studies in the dosage range of 500 – 1000 mg/day. The Curcugen study portfolio will continue to grow with additional clinical studies underway or in active peer review. Please contact our team for periodic updates.
Curcugen® is a suitable for a variety of formulations – traditional and novel food and beverage formats alike. Curcugen® is palate-friendly – requiring minimal flavoring and no masking, free flowing, highly dispersible and very stable. Many formulation concepts for Curcugen® have been explored, some of which include:
Applications
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- Encapsulation
- Tableting
- Ready to drink powder
- Ready to mix powder
- Oral dispersible powder
- Fast melts
- Soft chews
- Chocolate
- Hard candy/lozenges
Benefits
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- 39-times enhanced bioavailability (Free Curcumin)
- Supports overall well-being
- Antioxidant
- Reduces exercise-induced pain and discomfort
- Supports immunity
Composition
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- 98.5% turmeric-oleoresin extract
- 1.5% flow agent
Safety
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- Curcugen® has an LD50 > 5,000 mg/kg in an animal model, establishing it as a safe ingredient in an acute, single-dose model.
- A 90-day, chronic, repeat dose OECD-guided toxicity study in an animal model has also proven Curcugen® to be safe > 2000 mg/kg/day.
- Curcugen® has also proven not to produce genotoxicity or mutagenicity, as per OECD-testing procedures.
Clinical Research
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An extensive clinical study program for Curcugen® evaluating its efficacy at doses between 500-1000 mg/day has been initiated at both domestic and international universities and contract research organizations. The below list references those studies that have already been published. Contact our sales team to learn more about those that are ongoing.
- Swartz N, et al. A double-blinded, placebo-controlled trial evaluating the antiinflammatory effects of Curcugen in an acute exercise model. Journal of the International Society of Sports Nutrition 2020, 17(Suppl 2):A22.
FAQ
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Q: What is meant by next-GENeration curcumin?
A: The ‘next-GENeration’ label is being given to Curcugen™ because of its unique sourcing material and food-state matrix i.e.oleoresin, novel technology and the versatility of its formulation across the dietary supplement, food and beverage industry, as well as clinical study backing.
Q: What is Curcugen’s composition?
A: Curcugen™ is 98.5% turmeric-oleoresin derived, is standardized for 50% curcuminoids and contains both turmeric essential oils and ‘polar’ turmeric resins. Further, it contains 1.5% of a flow agent.
Q: What are ‘polar’ resins?
A: Turmeric oleoresins include resins that polar and non-polar in character. The SELF D™ technology is able to capture the polar resins, meaning those with an electrical charge. The benefit of the polar resins, which are novel to the Curcugen™ brand, is that when they are complexed with curcumin, they attract water toward the molecule, overcoming curcumin’s natural hydrophobicity. In a fluid medium the matrix is activated allowing for a slow release function and a dispersing quality.
Q: How is Curcugen different than turmeric oleoresin?
A: Curcugen is an optimized turmeric oleoresin extract. Through the Self-D technology, the more ‘polar’ resins are retained, along with some essential oils; they are complexed with curcuminoids, which are enriched to a 50% standard. Turmeric oleoresin itself contains resins in their natural form, not optimized for bioavailability and curcuminoids in a much smaller concentration.
Q: How is Curcugen different than 95% curcuminoids?
A: 95% curcuminoids are derived from turmeric oleoresin. 95% curcuminoids are a purified form of the oleoresin, whereby the essential oils and resins are lost during manufacturing. Again, Curcugen retains both essential oils and the more ‘functional’ resins, while maintaining a significantly substantial concentration of curcuminoids, at a 50% standard.
Q: How many more times bioavailable is Curcugen™ than unformulated curcumin?
A: Curcugen™ is X-times more bioavailable than unformulated/95%-curcumin, as demonstrated by a 18-subject cross-over design.
Q: What is the clinical dose for Curcugen™?
A: The clinical dose for Curcugen™ is 500 mg per day, based upon some preclinical data. Curcugen will be evaluated in clinical studies at this dose to confirm its effect in a variety of applications.
Q: Is Curcugen™ a clinically-studied ingredient?
A: Yes. Curcugen™ is being evaluated clinically. Two clinical trials have already been initiated on the ingredient. We expect data from these first (2) trials in the late Fall of 2019.
Q: Is Curcugen safe?
A. Comprehensive Safety studies for Curcugen™ are underway. The acute toxicity study is complete, resulting in a LD50 > 5,000 mg/kg and the sub-chronic, repeat dose, 90-day toxicity study has commenced.
The novel source of Curcugen, the turmeric oleoresin has been consumed as a natural part of the rhizome, in the traditional cuisine of Indian and other native cultures. Further, the oleoresin is used as source material for the flavor and food coloring industry, as the aromatic (flavor) component is associated with the essential oil, while the curcuminoids give rise to the characteristic yellow tint. Turmeric oleoresin has been established as safe.
Q: Is Curcugen™ GRAS?
A. Curcugen has not been established as GRAS as of yet, however it will be submitted for GRAS self-assessment in the coming months.
Q: Is Curcugen™ soluble in water?
A. No. Curcugen is not soluble in water. but it is water-dispersible.
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