Nitric oxide (NO) is one of the most important signaling molecules produced within the body. Continuous generation of NO is essential for the integrity of the cardiovascular system. The objective of the present study was to assess whether oral intake of a nitrate (NO3ˉ) rich dietary supplement (amaranth extract) is able to increase NO3ˉ and nitrite (NO2ˉ) levels in blood plasma and saliva of healthy adults.
In the present study, bioavailability and pharmacokinetics of NO3ˉ and NO2ˉ from amaranth extract (2 g as single dose) was studied in 16 healthy subjects and compared with placebo in a crossover design. The NO3ˉ and NO2ˉ levels in plasma as well as saliva were measured up to 24 h.
After administration of amaranth extract, the NO3ˉ level in plasma as well as saliva were found to be significantly (p<0.001) higher than that were found in the placebo group. The NO2ˉ level in plasma was slightly higher (p<0.05) in amaranth group (test group) as compared to that in the placebo group whereas saliva NO2ˉ level was significantly high (p<0.001) in amaranth extract-treated group than placebo group.
These results clearly indicate that a single oral dose of amaranth extract is able to increase the NO3ˉ and NO2ˉ levels in the body for at least eight hours. The increase in NO3ˉ and NO2ˉ levels can help in increasing the overall performance of people involved in vigorous physical activities or sports.
Medical Journal: European Journal of Applied Physiology
Authors: Haun, et al.
In a recent crossover, double-blind, placebo controlled human clinical study, Haun et al. determined the acute effect of a red spinach extract (RSE) high in inorganic nitrate on vascular reactivity. No significant changes in blood pressure (BP) or heart rate (HR) occurred in either group. The authors concluded that RSE significantly increased plasma nitrate 30-min post-ingestion.