Marine Collagen Tripeptides


Bioavailable Bioactive 15% Standardized

Marine Collagen Tripeptides


Bioavailable Bioactive 15% Standardized

Morikol is a marine collagen tripeptide formula. Tripeptides, as uniquely prepared in Morikol, are clinically proven to support skin and joint health at industry low doses. At dosages as low as 1g/day, Morikol’s very low molecular weight, tripeptide-formulation easily adapts to capsules, tablets, gummies and other novel formulations that are hard to achieve with bulkier collagen powders.

 

 

As as standardized source of tripeptides, Morikol innovatively avails small, low molecular weight peptides to the tissue when consumed orally. Research has described marine based collagen products as innately bioavailable, because they are smaller – species wise — than larger, land animal derived hydrosylates. Beyond this, Morikol’s proprietary enzymatic process further digests these already small protein-chains, resulting in the precision-cut delivery of targeted, very low molecular weight peptides (tripeptides that are ONLY 3-amino acids long) in standardized, bioactive quantities.

 

 

Tripeptides are digestion proof, absorbing intact through exclusive PEPT1 receptors in the intestines. Tripeptides have been found circulating in free form in the bloodstream and in tissue spaces, having shown chemotactic benefits similar to endogenous growth factors like platelet derived, and basic fibroblast growth factors (PDGF and BFGF). Furthermore, even dipeptides that are enzymatically cleaved from tripeptides by intestinal peptidases are shown to directly increase the proliferation of fibroblasts, (i.e. collagen synthesizing cells).

Morikol delivers over 150 mg of tripeptides per its recommended 1 gram/day dose, as a direct substrate for skin tissue healing and regeneration. Tripeptides have been shown to protect the skin from the photo-aging effects of UV-B light by reducing the production of MMPs (collagen digesting enzymes) produced from sun-exposed keratinocytes.

 

 

Clinical study of the tripeptides’ efficiency at stimulating collagen rebuilding and regeneration, hyaluronic acid and ceramide pathway activation, have validated its appreciable skin and joint support benefits. When evaluated at only 1 gram/day in maturing women with diagnosable, age-related skin damage, formulated tripeptides proved significant benefit over placebo in improving various skin change outcomes, as shown below.

 

 

With the average molecular weights of Morikol tripeptides averaging only 300 Da, the delivery of power packed collagen support has never been more convenient. Morikol is a low bulk powder at 1-2 grams per day and makes for the creative delivery of a clinically-proven tripeptides formulation that mild tasting, neutral-smelling and practical. Morikol can add unique value to your product line in the form of a gummy, capsule, gelcap, liquid formulation, sachet tablet and more.

 

Applications

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  • Powder for encapsulation
  • Gummies
  • Powder for sachet/tub
  • Powder for beverages

Benefits

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  • Promotes healthy skin
  • Protects skin from oxidative stress
  • Minimizes wrinkles and fine lines
  • Improves skin hydration
  • Reduces skin roughness

Composition

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MoriKol is a 100% piscine-sourced, collagen hydrolysate with a minimum of 15% of peptides in the easy-to-absorb, tripeptide format Gly-X-Y, where X and Y most commonly include proline, hydroxyproline and alanine. Its purity is verified by a NLT 6% hydroxyproline standard and it is free from any carriers or excipients.

Safety

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Collagen has been consumed by many people across the globe for many years and safety of it or the byproducts of its production have never presented any concerns for safety. Morikol® is produced with food-grade enzymes and is considered a safe product.

Clinical Research

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Formulated tripeptides, also known as a low molecular weight collagen peptide (LMWCP) has been the subject of a number of clinical and preclinical studies, proving collagen rebuilding, anti-aging and joint pain relief with only 1-2g/day. Morikol® skin-promoting benefits require a low, 1g/day, providing no less than 150 mg tripeptides. As a joint-support ingredient, Morikol® benefits begin at only 2 g/day. The below list of studies support these claims.

 Do-Un K, et al. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2018;10(826)

  1. Yamamoto S, et al. Effect of Collagen Tripeptide on Knee Osteoarthritis in Humans and Animals. Pharmacometrics. 2015;89 (5/6):115-124
  2. Pyun H-B, et al. Effects of Collagen Tripeptide Supplement on Photoaging and Epidermal Skin Barrier in UVB-exposed Hairless Mice. Prev Nutr Food Sci. 2012; 17: 245-253
  3.  Jung K, et al. The Efficacy of AP Collagen Peptides Intake on Skin Wrinkle, Elasticity, and Hydration Improvement. Journal of the Korean Society of Food Science and Nutrition 2021; 50(5): 429-436

FAQ

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Q: Is MoriKol tested for environmental contaminants?

A: Yes. MoriKol™ is assayed for and complies with all regulated limits of detection for 40+ antibiotics, PCBs and heavy metals including mercury, lead, arsenic and cadmium.

Q: Is MoriKol™ FMD and BSE-free?

A: Yes. MoriKol™ is 100% FMD and BSE-free, but this is by default – as these diseases do not develop in marine/pescine sources, but can be the result of unscrupulous practices in the rearing of land animals, i.e cows. The majority of collagen on the market is bovine (cow) sourced, so this can still pose even small concerns, even when a product certifies themselves as ‘BSE and FMD-free’, because low-level, untraceble levels or the prions that causes these diseases may persist in the source material, and can still transfer to the human or animal that consumes them.

Q: What marine source is MoriKol™ from?

A: MoriKol is sourced from the skin of Aquacultured fish.

Q: What is the molecular weight distribution?

A: The molecular weight of MoriKol is between 200-2000 Da, or < 1500 Da on average. The 15% tripeptide component of which average ~ 280 Da.

Q: Are there any allergens?

A: No. Our tests result show MoriKol to be devoid of any Egg, Gluten, Peanut, Soybean, Milk,  Almond, of Crustacean allergens.

Q: Don’t all collagen products have tripeptides?

A: Yes and No; most collagen products will have some very low molecular weight peptides, such as those in the low range under 300 Da – but the quantity thereof is quite negligible. Most hydrolyzed collagen products demonstrate a predictible bell curve, whereby the majority of peptides are in the middle of the bell curve, centered about the median peptide value. However, MoriKol’s low molecular weight collagen peptides (LMWCP), tripeptide formulation, shows a much more skewed curve, with two peaks showing a significant portion of peptides in the tripeptide range. This is the minimum 15% standard that we promote. Conversely, tripeptides in most other collagen hydrosylates are in the low 0-1% range.

Q:  What does the 15% tripeptide standard have to do with bioavailability?

A: Bi- and Tripeptides of collagen are the smallest absorbable peptide units. They have both been measured in the serum intact, either meaning that bipeptides have been predigested from tripeptides and absorbed, or that they too are absorbed directly from their available source material. MoriKol’s LMWCP deliver a 15% concentration of tripeptides, whereby in other products this amount is not guaranteed, and moreover tend to be available in negligible quantities. Because bi- and tripeptides are absorbed intact (i.e. more bioavailable), and/or require minimal predigestion activities, their action is more direct and predictable. Bi and tripeptides directly serve as collagen repair buidling blocks, or through indirect action, stimulate fibrobrast recruitment and collagen deposition, and activate hyaluronic acid and ceramide synthesis pathways.

Q: What does bioavailability have to do with bioefficacy?

A. Because more tripeptides are predictably and directly delivered to the body (e.g. areas of collagen breakdown), the results of a 64-women DBPCR-trial has shown remarkable results at an industry-low dose of the LMWCP tripeptide formulation of only 1g/day. Additionally, some of the beneficial results of formulated tripeptides showed significance as early as 6 weeks after intake. Most hydrolyzed collagen products show beneficial effects at higher doses, and often times after 12-weeks of intake.

Q:  What is the importance of 1g/day dose?

A: Being able to supply a clinically-proven dose of collagen at 1g/day is completely novel. The molecular weight of a product has a lot to do with the amount of bulk/room it occupies. Larger molecular weight collagen hydrolysate products, therefore traditionally required high doses. As hydrolysates have gotten smaller and smaller over time, the required doses to obtain clinical value has also come down, yet none have come down as low as MoriKol™.

For this reason, nearly all collagen products on the market are sold in tubs, or containers with free flowing powder and scoop/tablespoon sizes are required per day. Generally holding about 500 mg, encapsulated collagen products are definitely availabeon the market, they tend not to sell as well as powders – as the requirement is often times 6-10, or even 20 capsules per day. Capsules are supposed to a convenient delivery system, but this is definitely NOT convenient! MoriKol’s full dose can be obtained in ONLY (2) capsules/d.

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