Research & Development

Hinged from DolCas Biotech’s mission is our commitment to innovation. Our strong research and development team is equipped with an array of high-tech instrumentation and an onsite animal house. This combination conveniently and uniquely allows for the analysis, quantification, isolation, ranking and preliminary testing of phytochemicals with medicinal potential.



LC-MSLiquid chromatography paired with a mass spectrum detector presents a dynamic tool for separation, identification and quantification of molecules. Whereas HPLC is a good isolation instrument, it is limited in its ability to provide pure, single chemical results. But by ionizing and then putting an isolate of interest through the Mass Spectrometer, its discriminant comparison against a database or standard makes identification much more precise. Additionally, this combination allows for isomer detection, which MS alone cannot provide. 1


UPLCUltra Performance Liquid Chromatography optimizes the separation capacity of its 30-year predecessor, HPLC, by reducing the particle size of the sample and the flow pressure rate at which it is sensed. Eco-friendly increases in speed, sensitivity and resolution are achieved in this evolution of HPLC. Matched with a photo diode array (PDA) sensor, improved detection of trace impurities and sensitivity in quantitation of analyte is afforded. The precision of this instrument is used for setting standards for content or quality of important molecules/compounds. 2


A more flexible version of UPLC, allowing more autonomous control of speed, sensitivity and resolution by the researcher in separating, identifying and quantifying molecules. 3


Flash-chromatographyAs the name implies, Flash CG is a rapid purification technique similar to preparative HPLC. Suitable for bulk separation or for routine procedure, where the efficiency of separation is not of consequence, lower cost Flash CG is a viable alternative to HPLC. 4


GEN-VAC-EZ-2Drying solvent-extracted naturally resourced samples is one of the most time-consuming processes in the pre-analytic and concentrating phases of product development. In remaining cutting-edge and innovative in this industry, time is of the essence. The Gen Vac EZ-2 vacuum evaporation system expedites this tedious process, so our research and development team can spend more time discovering “scientifically and clinically proven, consumer demanded ingredients.” 5


(LC-MS: Why use it, and what is it?)

(ME, 2005)

(Nexera UHPLC, 2015)

(Lloyd L, 2010)

(Rapid Evaporation for Natural Product Extraction)

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9 Lenel Road
Landing, NJ 07850
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